(P015) TRENDS AND DISPARITIES IN THE BURDEN OF INFLAMMATORY BOWEL DISEASE IN MISSOURI OVER THREE DECADES

Background: Chronic diseases such as Inflammatory Bowel Disease (IBD) place a considerable health and economic strain on Missouri, a situation expected to worsen as the population ages¹. Given the higher incidence rates of IBD observed in the Midwest², this study examines the longitudinal trends in incidence, prevalence, mortality, and Disability-Adjusted Life Years (DALY) of IBD in Missouri over 31 years. It focuses on age and gender variations to provide insights that may assist policymakers and stakeholders in informed decision-making.


Methods: Data were sourced from the Global Burden of Disease (GBD) dataset, focusing on Crude and Age-Adjusted Incidence, Prevalence, DALYs, and Death Rates from 1990 to 2021. Using SPSS 29, we calculated the annual percentage changes to track these indicators' evolution.


Results: From 1990 to 2021, the burden of IBD in Missouri has shown notable epidemiological shifts. Crude prevalence rates increased by 22.39% from 10,829.18 to 13,254.01 per 100,000, while age-standardized prevalence rates decreased by 10.48%. Meanwhile, DALY rates have increased significantly; crude measures rose by 70.78%, and age-standardized rates by 18.78%, this increase was more pronounced among the elderly. The majority of DALYs were due to Years Lived with Disability (YLDs) rather than Years of Life Lost (YLLs), with rates in females rising from 39.97 to 50.14 and in males from 40.91 to 45.56, highlighting significant gender differences.


Discussion: The data reveal a growing burden of IBD in Missouri, with rising DALYs and crude prevalence rates, contrasting with national trends showing a decrease in age-standardized DALY rates in the United States³. The growth in DALYs, especially among the older demographic, underscores the chronic nature of IBD and the aging population's vulnerability⁴, necessitating enhanced management strategies and healthcare services tailored to this group⁵. Gender differences in prevalence and DALY rates suggest varied experiences with IBD, influenced by biological, environmental, or access-related factors.


Conclusion: The increasing epidemiological burden of IBD in Missouri calls for continued research and development of targeted healthcare interventions. Effective resource allocation and the adoption of gender-specific approaches are critical to mitigating IBD's growing impact, particularly as the population ages.